MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C92A36.8ACA15B0" Questo documento è una pagina Web in file unico, nota anche come archivio Web. La visualizzazione di questo messaggio indica che il browser o l'editor in uso non supporta gli archivi Web. Scaricare un browser che supporti gli archivi Web, come Microsoft Internet Explorer. ------=_NextPart_01C92A36.8ACA15B0 Content-Location: file:///C:/C9965AE1/MGUSStudioepidemiologiconellaRepubblicadiSanMarino-Dott.saBellavista.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" GAMMAPATIA MONOCLONALE DI INCERTO SIGNIFICATO: studio epidemiologico nella Repubblica di San Marino Bugli AM1, Casali F2, Nocentini F2, Stacchi= ni MA2, Marchegiani G1, Paolini P1, Gualtieri A3, Sacchini E3, Bellavista L4. Ricci P5 1UOC Medicina Generale

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file:///C:/C9965AE1/MGUSStudioepidemiologiconellaRepubblicadiSanMarino-Dott.saBellavista_file/slide0009.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" GAMMAPATIA MONOCLONALE DI INCERTO SIGNIFICATO: studio epidemiologico nella Repubblica di San Marino Bugli AM1, Casali F2, Nocentini F2, Stacchi= ni MA2, Marchegiani G1, Paolini P1, Gualtieri A3, Sacchini E3, Bellavista L4. Ricci P5 1UOC Medicina Generale
3Dab.jpg
GAMMAGLOBULINA
o
IMMUNOGLOBULINA
o
ANTICORPO:
Proteina del siero
Prodotta dalle plasmacellule
Difende l’organismo dagli agenti nocivi (batteri, virus…)
STRUTTURA:
Due catene pesanti di tipo G, A, M, D, E =
Due catene leggere di tipo k, λ
̶= 6;GAMMAPATIA: alterazione delle gammaglobuline
Gam= mapatia Monoclonale di Incerto Significato (MGUS)
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file:///C:/C9965AE1/MGUSStudioepidemiologiconellaRepubblicadiSanMarino-Dott.saBellavista_file/slide0010.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" GAMMAPATIA MONOCLONALE DI INCERTO SIGNIFICATO: studio epidemiologico nella Repubblica di San Marino Bugli AM1, Casali F2, Nocentini F2, Stacchi= ni MA2, Marchegiani G1, Paolini P1, Gualtieri A3, Sacchini E3, Bellavista L4. Ricci P5 1UOC Medicina Generale
̶= 6;Le gammaglobuline si identificano tramite un esame= di laboratorio su siero:
̶= 6;ELETTROFORESI SIERO-PROTEICA
Le Gammaglobuline (Ig)
CAMPO ELETTRICO
<= /div>
<= /div>
MIGRAZIONE DELLE PROTEINE SECONDO <= span style=3D'position:absolute;top:51.24%;left:60.86%;width:32.2%;height:4.0%'= >LA LORO STRUTTURA
=
=
TRACCIATO ELETTROFORETICO
Le immunoglobuline si trovano in zona gamma e <= /span>in zona beta del tracciato elettroforetico.
immunoglobuline
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Ricci P5 1UOC Medicina Generale
= SOGGETTO NORMALE: assortimento di tutti gli anticorpi (IgG, IgA, IgM..k e λ), policlonalità
= SOGGETTO MGUS: prevale un solo tipo di anticorpo (es. IgM k) che viene = definito MONOCLONALE poiché prodotto da un clone di plasmacellule
Gammap= atia Monoclonale= di Incerto Significato (MGUS)
MONOCLONALE:
3Dscan02
Componente = monoclonale
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